Electroporation of the Liver: More Than 2 Concurrently Active, Curved Electrodes Allow New Concepts for Irreversible Electroporation and Electrochemotherapy
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چکیده
منابع مشابه
Electrochemotherapy (ECT) and irreversible electroporation (IRE) -advanced techniques for treating deep-seated tumors based on electroporation
* Correspondence: Damijan. [email protected] University of Ljubljana, Faculty of Electrical Engineering, Ljubljana, 1000, Slovenia When a cell is exposed to a sufficiently intense electric field (for a sufficient duration), local defects in the cell membrane appear and become permeable to molecules that otherwise cannot pass through it. This phenomenon is commonly known as electroporation ...
متن کاملTreatment planning of electroporation-based medical interventions: electrochemotherapy, gene electrotransfer and irreversible electroporation.
In recent years, cancer electrochemotherapy (ECT), gene electrotransfer for gene therapy and DNA vaccination (GET) and tissue ablation with irreversible electroporation (IRE) have all entered clinical practice. We present a method for a personalized treatment planning procedure for ECT, GET and IRE, based on medical image analysis, numerical modelling of electroporation and optimization with th...
متن کاملElectroporation for Electrochemotherapy and Gene Therapy
The theoretical understanding of the phenomenon of electroporation is crucial for planning and optimization of protocols for drug and/or gene delivery. In the last four decades, a number of tentative theoretical descriptions of this phenomenon have been proposed, assuming either deformation of membrane lipids,1–3 their phase transition,4 breakdown of interfaces between the lipid domains,5 or de...
متن کاملTumor Ablation with Irreversible Electroporation
We report the first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice. Irreversible electroporation is a newly developed non-thermal tissue ablation technique in which certain short duration electrical fields are used to permanently permeabilize the cell membrane, presumably through the formation of nanoscale def...
متن کاملAn update on irreversible electroporation of liver tumours.
OBJECTIVE. To investigate the clinical efficacy and safety of irreversible electroporation for ablation of liver tumour in humans. DATA SOURCES. The PubMed and MEDLINE databases were systematically searched. STUDY SELECTION. Clinical research published in English in the last 10 years until October 2013 that address clinical issues related to irreversible electroporation of human liver tumours w...
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ژورنال
عنوان ژورنال: Technology in Cancer Research & Treatment
سال: 2018
ISSN: 1533-0346,1533-0338
DOI: 10.1177/1533033818809994